Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel

By David T. Curiel

Adenoviral Vectors for Gene remedy, moment Edition offers specified, accomplished insurance of the gene supply automobiles which are according to the adenovirus that's rising as a huge instrument in gene remedy. those interesting new healing brokers have nice strength for the remedy of affliction, making gene remedy a fast-growing box for study.

This ebook offers subject matters starting from the fundamental biology of adenoviruses, throughout the development and purification of adenoviral vectors, state of the art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory concerns surrounding human medical gene treatment trials. This vast scope of data presents a superb evaluate of the sphere, permitting the reader to achieve a whole knowing of the advance and use of adenoviral vectors.

  • Provides entire insurance of the elemental biology of adenoviruses, in addition to their development, propagation, and purification of adenoviral vectors
  • Introduces universal techniques for the improvement of adenoviral vectors, in addition to state-of-the-art tools for his or her improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses software of adenoviral vectors in animal sickness models
  • Considers Federal Drug management laws for human medical trials

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Sample text

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor. J Biol Chem 2006;281:33704–16. Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, et al. Adenovirus type 11 binding alters the conformation of its receptor CD46. Nat Struct Mol Biol 2007;14:164–6. Persson BD, Schmitz NB, Santiago C, Zocher G, Larvie M, Scheu U, et al. Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens.

An arginine switch in the species B adenovirus knob determines high-affinity engagement of cellular receptor CD46. J Virol 2009;83:673–86. Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, et al. Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. J Virol 2007;81:12785–92. Wang H, Yumul R, Cao H, Ran L, Fan X, Richter M, et al. Structural and functional studies on the interaction of adenovirus fiber knobs and desmoglein 2. J Virol 2013;87:11346–62.

Maturation and encapsidation. Virology 1980;101:144–56. Chroboczek J, Viard F, D’Halluin JC. Human adenovirus 2 temperature-sensitive mutant 112 contains three mutations in the protein IIIa gene. Gene 1986;49:157–60. San Martin C, Glasgow JN, Borovjagin A, Beatty MS, Kashentseva EA, Curiel DT, et al. Localization of the N-terminus of minor coat protein IIIa in the adenovirus capsid. J Mol Biol 2008;383:923–34. Lehmberg E, Traina JA, Chakel JA, Chang RJ, Parkman M, McCaman MT, et al. Reversed-phase high-performance liquid chromatographic assay for the adenovirus type 5 proteome.

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